ASCO-GU 2020 前立腺癌関連演題一覧
ESPOIR Vol. 3 No. 1
Abstract No.
Title

1st Author

8
Circulating tumor DNA (ctDNA) to detect neuroendocrine prostate cancer genomic and DNA methylation changes.

Himisha Beltran

9
A prospective phase II/III multicenter study of PSMA-targeted 18F-DCFPyL PET/CT imaging in patients with prostate cancer (OSPREY): A sub-analysis of regional and distant metastases detection rates at initial staging by 18F-DCFPyL PET/CT.

Frederic Pouliot

10
Surveillance or metastasis-directed therapy for oligometastatic prostate cancer recurrence (STOMP): Five-year results of a randomized phase II trial.

Piet Ost

15
Pembrolizumab (pembro) plus enzalutamide (enza) for enza-resistant metastatic castration-resistant prostate cancer (mCRPC): KEYNOTE-199 cohorts 4-5.

Julie Nicole Graff

16
Pain response and health-related quality of life (HRQL) analysis in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving cabazitaxel (CBZ) versus abiraterone or enzalutamide in the CARD study.

Karim Fizazi

18
The association between PSA pattern changes and progression in patients with metastatic hormone-sensitive prostate cancer (mHSPC) treated with abiraterone and prednisone (AA/P).

Iris Yeong- Fung Sheng

19
Impact of 18F-fluciclovine PET on salvage radiotherapy plans for men with post-radical prostatectomy recurrence of prostate cancer.

Heather Ann Payne

22
The effect of androgen deprivation therapy on 68GA-PSMA-tracer uptake in nonmetastatic prostate cancer patients.

Onal Cem

23
FDG and PSMA PET in metastatic castration-resistant prostate cancer (mCRPC).

Katherine A. Zukotynski

24
Differential expression of PSMA and 18F-fluciclovine transporter genes in metastatic castrate-resistant and treatment-emergent small cell/neuroendocrine prostate cancer.

Carissa Chu

25
A deep learning algorithm to predict coexisting metastatic disease using intraprostatic [F18]DCFPYL PSMA image alone in veterans with prostate cancer.

Nicholas George Nickols

27
A multivariate logistic regression model based on 3T mpMRI, clinical, and biopsy parameters for the prediction of prostate cancer extracapsular extension.

Sohrab Afshari Mirak

28
Non-prostate cancer malignancies detected by 18F-Fluciclovine PET/CT.

Andrew R. Barsky

29
Real-world management of advanced prostate cancer: A Canadian comparison of academic specialists and community-based prostate cancer physicians.

Sebastien J. Hotte

30
Clinical outcomes of abiraterone acetate + prednisone (AA) + bone resorption inhibitors (BRI) versus AA alone as first-line therapy for castration-resistant prostate cancer (CRPC) with bone metastases (BM) in an international multicenter database.

Edoardo Francini

31
Late dosing of luteinizing hormone-releasing hormone agonists (LHRH) and testosterone (T) levels >20 ng/dL in prostate cancer (PCa).

Przemyslaw Twardowski

32
Clinical outcomes and patient (pt) profiles in REASSURE: An observational study of radium-223 (Ra-223) in metastatic castration-resistant prostate cancer (mCRPC).

Celestia S. Higano

33
Real-world analysis of prostate-specific antigen (PSA) outcomes among patients with metastatic castration-resistant prostate cancer (mCRPC) treated with enzalutamide (ENZA).

Stephen J. Freedland

36
Edmonton Prostate Interdisciplinary Cancer Clinic (EPICC): Real-world efficacy outcomes of a multidisciplinary clinic for metastatic castration-resistant prostate cancer.

Graeme Follett

37
Long-term health-related quality-of-life outcomes in a racially diverse cohort of prostate cancer patients receiving retropubic versus robotic prostatectomy.

Galen Conti

39
5-alpha reductase inhibitors (5-ARI) and prostate cancer mortality among men with regular access to screening and health care.

Lorelei A. Mucci

40
Overall survival (OS) in men with chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) receiving bicalutamide (BIC) followed by enzalutamide (ENZA) or abiraterone (ABI).

Daniel J. George

41
Fracture rates in radium223 (Ra223) treated mCRPC patients (pts): A real-world analysis in 177 pts treated at a single community center 2010-2018.

Yen Thi Kim Hong Cao

42
Overall survival (OS) among Medicare beneficiaries receiving sipuleucel-T (sip-T) versus oral treatment for metastatic castration-resistant prostate cancer (mCRPC).

Rana R. McKay

43
Response to olaparib or carboplatin in a real-world cohort of men with DNA damage repair (DDR) deficient metastatic castration-resistant prostate cancer (mCRPC).

Jacob E Berchuck

44
Prevalence and clinical impact of BRCA1/2 mutations in patients with de novo metastatic hormone-sensitive prostate cancer (mHSPC).

Nieves Martinez Chanza

45
Patient-reported outcomes (PRO) from a phase I/II dose-escalation study of fractionated dose 177Lu-PSMA-617 for progressive metastatic castration-resistant prostate cancer (mCRPC).

Panagiotis J. Vlachostergios

48
Real-world survival improvements in patients with newly diagnosed metastatic prostate cancer treated in the United States.

Carlo Cattrini

49
Association of area social determinants of health with prostate cancer mortality.

John Clark Henegan

50
Concurrent or layered treatment (Tx) with radium-223 (Ra-223) and enzalutamide (Enza) or abiraterone plus prednisone/prednisolone (Abi/pred): A retrospective study of real-world clinical outcomes in patients (pts) with metastatic castration-resistant pros

Neal D. Shore

51
A risk scoring system for African-American (AA) patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) treated with first-line abiraterone (ABA) or enzalutamide (ENZ).

Jacqueline T Brown

52
The real-world efficacy of abiraterone acetate (ABA) and docetaxel (DOC) in the treatment of African-American (AA) patients (pts) with metastatic castration-sensitive prostate cancer (mCSPC).

Katherine E.R. Smith

53
Health-related quality of life (HRQoL) patient-reported outcomes (PROs) and survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts).

Lorente David

54
Veterans affairs (VA) prostate cancer treatment (Tx) sequencing (VAPCaTS): A real-world study.

Stephen J. Freedland

56
Variance in symptom assessment between patient and caregiver: A prospective study of patients staged as metastatic prostate cancer—An interim analysis.

Sadie Swift

57
Health care team and treatment decision-making experiences among prostate cancer patients.

Nicole E. Nicksic

59
The National Radium-223 Dichloride Audit Group: Data from patients in United Kingdom oncology centers with metastatic castration-resistant prostate cancer treated with radium-223 dichloride.

Manreet Randhawa

60
Using natural language processing (NLP) tools to identify veterans with metastatic prostate cancer (mPCa).

Patrick R. Alba

62
A retrospective review of the effect of metformin in metastatic prostate cancer.

So Yi Lam

63
Treatment response comparisons between ATM and BRCA2 germline carriers for mCRPC.

Alexandra Sokolova

64
Genomic profiling of prostate cancer at a diverse academic center.

Robert Lopez

65
Tumor protein expression of BRCA1 and development of lethal prostate cancer.

Carl Ceraolo

67
Mental perception of prostate cancer (PCa) disease in patients aged 60 years and older initiating gonadotropin-releasing hormone agonist (GnRHa) therapy.

Christophe Hennequin

68
Financial hardship among Medicare beneficiaries prescribed oral targeted therapies for advanced prostate cancer.

Megan Veresh Caram

69
Epidemiology and regional variation in the mortality of patients admitted with prostate cancer in the United States.

Arya Mariam Roy

72
Prevention of docetaxel-associated febrile neutropenia with primary granulocyte colony-stimulating factors (GCSF) in Chinese metastatic hormonal-sensitive (mHSPC) and castration-resistant prostate cancer (mCRPC).

Darren M.C. Poon

73
The effect of docetaxel, enzalutamide, abiraterone, and radium-223 on cognitive function in older men with metastatic castrate-resistant prostate cancer (mCRPC).

Shabbir M.H. Alibhai

75
Predicting toxicity-related docetaxel discontinuation and survival in metastatic castration-resistant prostate cancer (mCRPC) using open phase III trial data.

Anish B. Parikh

77
Exenterative surgery to improve quality of life on men with locally advanced, symptomatic castration-resistant prostate cancer.

Friederike Haidl

78
Treatment outcomes for metastatic castrate-resistant prostate cancer (mCRPC) patients (pts) following docetaxel (D) for hormone sensitive disease.

Andrew Lachlan Schmidt

79
ModraDoc006, an oral docetaxel formulation in combination with ritonavir (ModraDoc006/r), in metastasized castration-resistant prostate cancer (mCRPC): A multicenter phase I study.

Marit Vermunt

80
Propensity score matched comparison of docetaxel and androgen receptor axis-targeted (ARAT) agents in castration-resistant prostate cancer patients with intraductal carcinoma of the prostate (IDC-P).

Akiyuki Yamamoto

81
The use of intermittent enzalutamide dosing in the treatment of metastatic castrate-resistant prostate cancer.

Michael Rowe

82
Time to second progression (PFS2) in patients (pts) from TITAN with metastatic castration-sensitive prostate cancer (mCSPC) by first subsequent therapy (hormonal vs. taxane).

Neeraj Agarwal

83
PT-112 in advanced metastatic castrate-resistant prostate cancer (mCRPC), as monotherapy or in combination with PD-L1 inhibitor avelumab: Findings from two phase I studies.

Alan Haruo Bryce

84
Abiraterone acetate (AA) with or without cabazitaxel (CBZ) in treatment of chemotherapy naive metastatic castration-resistant prostate cancer (mCRPC).

Susan F. Slovin

85
Bicalutamide with or without metformin for biochemical recurrence in prostate cancer patients (BIMET-1).

Marijo Bilusic

86
Phase II study of cabazitaxel (CAB) plus enzalutamide (ENZ) in metastatic castration-resistant prostate cancer (mCRPC).

Julie Nicole Graff

87
Apalutamide (APA) for metastatic castration-sensitive prostate cancer (mCSPC) in TITAN: Outcomes in patients (pts) with low- and high-risk disease.

Mustafa Ozguroglu

90
SHR3680, a novel antiandrogen, for the treatment of metastatic castration-resistant prostate cancer (mCRPC): A phase I/II study.

Xiaojian Qin

91
Phase I/II trial of enzalutamide (Enz) plus mifepristone (Mif) for metastatic castration-resistant prostate cancer (mCRPC).

Anthony Serritella

92
Impact of upstream use of novel hormonal therapy on progression of patients (pts) to metastatic castration-resistant prostate cancer (mCRPC) in the United States (US).

Howard I. Scher

93
Oligopelvis-GETUG P07: A multicenter phase II trial of combined salvage radiotherapy and hormone therapy in oligorecurrent pelvic node relapses of prostate cancer.

Stephane Supiot

94
Phase II trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer.

Mitchell E. Gross

95
Randomized phase II study of docetaxel (D) + abiraterone acetate (AA) versus D after disease progression to first-line AA in metastatic castration-resistant prostate cancer (mCRPC): ABIDO-SOGUG Trial.

Miguel Angel Climent Duran

96
Disulfiram (DSF) pharmacokinetics (PK) and copper PET imaging in a phase Ib study of intravenous (IV) copper loading with oral DSF for patients with metastatic castration-resistant prostate cancer (mCRPC).

Tian Zhang

97
Phase II trial of a novel immunotherapy combination of pembrolizumab and HER2 bi-armed activated T cells (BATs) in metastatic castrate resistant prostate cancer.

Meera Patel

99
MEDI3726, a prostate-specific membrane antigen (PSMA)-targeted antibody-drug conjugate (ADC) in mCRPC after failure of abiraterone or enzalutamide.

Johann S. De Bono

100
KEYNOTE-365 cohort A updated results: Pembrolizumab (pembro) plus olaparib in docetaxel-pretreated patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

Evan Y. Yu

101
Prostate-directed radiation therapy and overall survival for men with M1a prostate cancer.

David Dewei Yang

102
KEYNOTE-365 cohort C updated results: Pembrolizumab (pembro) plus enzalutamide (enza) in abiraterone (abi)-pretreated patients (pts) with metastatic castrate-resistant prostate cancer (mCRPC).

William R. Berry

103
KEYNOTE-365 cohort B updated results: Pembrolizumab (pembro) plus docetaxel and prednisone in abiraterone (abi) or enzalutamide (enza)-pretreated patients (pts) with metastatic castrate-resistant prostate cancer (mCRPC).

Michael Paul Kolinsky

104
Update on KEYNOTE-199, cohorts 1-3: Pembrolizumab (pembro) for docetaxel-pretreated metastatic castration-resistant prostate cancer (mCRPC).

Emmanuel S. Antonarakis

105
PSA progression compared to radiographic or clinical progression in metastatic castration-resistant prostate cancer patients treated with enzalutamide.

Shruti U. Gandhy

106
Survival outcomes and risk group validation from SWOG S0925, a randomized phase II study of androgen deprivation (AD) +/- cixutumumab, in new metastatic hormone-sensitive prostate cancer (mHSPC).

Risa Liang Wong

107
Association of tumor burden with the eligibility of upfront therapy in patients with castration-naive prostate cancer: A multicenter retrospective study.

Hiromichi Iwamura

109
Docetaxel (DOC) versus new androgen receptor-targeted agent (ART) in metastatic castrate-resistant prostate cancer (mCRPC) patients (pts) having received abiraterone (ABI) or enzalutamide (ENZA) as first-line (L1).

Antonin Broyelle

110
Analysis of the prognostic significance of circulating tumor DNA (ctDNA) in metastatic castrate-resistant prostate cancer (mCRPC).

Justin Shaya

111
Randomized phase II study of olaparib with or without cediranib in men with metastatic castration-resistant prostate cancer (mCRPC).

Joseph W. Kim

113
Systemic therapy for nonmetastatic castrate-resistant prostate cancer (M0 CRPC): A systematic review and network meta-analysis (NMA).

Ellen Cusano

114
Dose-escalation results of a phase I study of 225Ac-J591 for progressive metastatic castration resistant prostate cancer (mCRPC).

Scott T. Tagawa

115
Association of body composition with survival and efficacy of first-line treatment in patients with castration-resistant prostate cancer.

Jae Young Joung

116
A phase II randomized trial of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr (ORIOLE).

Phuoc T. Tran

117
Analysis of prevalence and prognostic implications of early versus delayed PSA declines during radium-223 (Ra223) treatment among men with metastatic castration-resistant prostate cancer (mCRPC).

Amanjot Sidhu

118
Niraparib in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and biallelic DNA-repair gene defects (DRD): Correlative measures of tumor response in phase II GALAHAD study.

Matthew Raymond Smith

119
TALAPRO-1: A phase II study of talazoparib (TALA) in men with DNA damage repair mutations (DDRmut) and metastatic castration-resistant prostate cancer (mCRPC)—First interim analysis (IA).

Johann S. De Bono

120
Results of a phase I/II prospective dose-escalation trial evaluating safety and efficacy of combination 177LuPSMA-617 and NOX66 in men with mCRPC post androgen signalling inhibition and two lines of taxane chemotherapy (LuPIN trial).

Louise Emmett

121
Overall survival using radium-223 (Ra223) in metastatic castrate-resistant prostate cancer (mCRPC) patients with and without DNA damage repair (DDR) defects.

Maarten J. van der Doelen

122
Phase Ib study of niraparib plus androgen receptor-targeted therapy (ART) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

Fred Saad

123
Enzalutamide (E) re-challenge as second-line in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) treated with first-line enzalutamide + docetaxel (D): Preliminary results of a post-progression analysis of CHEIRON trial.

Orazio Caffo

124
Phase I study of pasotuxizumab (AMG 212/BAY 2010112), a PSMA-targeting BiTE (Bispecific T-cell Engager) immune therapy for metastatic castration-resistant prostate cancer (mCRPC).

Horst-Dieter Hummel

125
Randomized phase II trial of radium-223 (RA) plus enzalutamide (EZ) versus EZ alone in metastatic castration-refractory prostate cancer (mCRPC): Long-term follow up of secondary endpoints.

Benjamin Louis Maughan

126
KEYNOTE-046 (Part B): Effects of ADXS-PSA in combination with pembrolizumab on survival in metastatic, castration-resistant prostate cancer patients with or without prior exposure to docetaxel.

Mark N. Stein

127
A pilot study of docetaxel and carboplatin for treatment of patients with mCRPC containing biallelic inactivation of genes in the BRCA1/2 pathway.

Heather H. Cheng

129
Adenosine receptor blockade with ciforadenant +/- atezolizumab in advanced metastatic castration-resistant prostate cancer (mCRPC).

Lauren Christine Harshman

130
Randomized phase II study of sipuleucel-T (SipT) with or without radium-223 (Ra223) in men with asymptomatic bone-metastatic castrate-resistant prostate cancer (mCRPC).

Catherine Handy Marshall

131
Novel androgen receptor inhibitors in nonmetastatic castration-resistant prostate cancer: A network meta-analysis.

Amanda Elizabeth Hird

132
Revision of CHAARTED and LATTITUDE criteria among Japanese de novo metastatic prostate cancer patients.

Shinichi Sakamoto

133
The effect of AKR1C3 on the switch from prednisone to dexamethasone in metastatic castration-resistant prostate cancer patients receiving abiraterone.

Yuchao Ni

134
PROfound: Efficacy of olaparib (ola) by prior taxane use in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and homologous recombination repair (HRR) gene alterations.

Johann S. De Bono

135
Surgical management versus combination radiotherapy in Gleason score 9-10 prostate cancer.

Edward Christopher Dee

138
Clinical investigation of neuroendocrine differentiation in prostate cancer.

Tatsuya Shimomura

139
Cabozantinib (C) in combination with atezolizumab (A) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Results of Cohort 6 of the COSMIC-021 Study.

Neeraj Agarwal

140
Safety of BXCL701, a small molecule inhibitor of dipeptidyl peptidases (DPP), with pembrolizumab, (pembro, anti-PD-1) monoclonal antibody, in men with metastatic castration-resistant prostate cancer (mCRPC).

Rahul Raj Aggarwal

142
IND candidate EPI-7386 as an N-terminal domain androgen receptor inhibitor in development for the treatment of prostate cancer.

Ronan Le Moigne

143
Role of metastases-directed therapy (MDT) in the management of solitary metastatic prostate cancer.

Mohamed E. Ahmed

144
Non-rising PSA disease progression on C-11 choline PET/CT imaging in patients receiving second generation hormone therapies (2nd-HT).

Mohamed E. Ahmed

145
ADRB2 expression in progressive metastatic castration-resistant prostate cancer.

Daniel Kwon

146
A prospective study of the relationship between clinical outcomes of enzalutamide and serum androgen levels measured by LC-MS/MS in patients with CRPC.

Yoshiyuki Miyazawa

147
Circulating tumor cell (CTC) genomic signatures of hormone therapy resistance in men with metastatic castration-resistant prostate cancer (mCRPC).

Santosh Gupta

149
The impact of the expression of the transcription factor MYBL2 on outcomes of patients with localized and advanced prostate cancer.

Yuki Yoshikawa

150
Checkpoint kinase inhibition in prostate cancer cells resistant to poly ADP-ribose polymerase inhibitors.

Mohammad Omar Atiq

151
New patient-derived models of castrate-sensitive and castrate-resistant prostate cancer.

Mitchell Lawrence

152
The tumor immune microenvironment of germline BRCA1/2 and sporadic prostate cancer.

Anna S. Trigos

154
Gene expression in circulating tumor cells (CTC) and plasma androgen receptor (AR) gene copy number (CN) for castration-resistant prostate cancer (CRPC) patients (pts) treated with cabazitaxel.

Giorgia Gurioli

155
Combination of AMG 160, a PSMA x CD3 half-life extended bispecific T-cell engager (HLE BiTE) immune therapy, with an anti-PD-1 antibody in prostate cancer (PCa).

Katherine L. Paweletz

156
Linking the Aggressive Variant Prostate Cancer (AVPC) molecular signature (-ms) to androgen indifference in a prospective clinical trial.

Paul Vincent Viscuse

157
Defining the monocyte subset transcriptional signature associated with progression during androgen-target therapy in prostate cancer patients.

Karen Angelica Cavassani

158
Intermediate atypical carcinoma (IAC): A discrete subtype of metastatic castration-resistant prostate cancer (mCRPC) suggesting that treatment-associated small cell/neuroendocrine prostate cancer (t-SCNC) may evolve from mCRPC adenocarcinoma (adeno)—Resul

Eric Jay Small

160
Plasma circulating tumor DNA (ctDNA) based clinical outcomes in metastatic castration-resistant prostate cancer (mCRPC).

Manish Kohli

162
Luminal B subtype as a predictive biomarker of docetaxel benefit for newly diagnosed metastatic hormone sensitive prostate cancer (mHSPC): A correlative study of E3805 CHAARTED.

Anis Hamid

163
MicroRNA-based biomarkers of the radiation response in prostate cancer.

Joanne B. Weidhaas

164
Association of high plasma glutamine levels with outcome in metastatic castration-resistant prostate (mCRPC) patients treated with taxanes.

Veronica Pereira Diaz

165
Association of neuroendocrine (NE) mRNA expression profiling in hormone-sensitive tumors samples with adverse clinical outcome in castration-resistant prostate cancer (CRPC) patients.

Mayra Orrillo

166
Targeting tumor-associated macrophage (TAM) mediated inhibition of T-cell migration in prostate cancer using epigenetic modifying agents.

David Kosoff

167
Genomic alterations in visceral versus nonvisceral “metastatic” site tumor tissue in metastatic prostate cancer (mPC).

John Esther

168
Association of very small nuclear circulating tumor cell (vsnCTC) with clinical outcomes in metastatic castration-resistant prostate cancer.

Jasmine Jiemei Wang

170
Prostate cancer CTC-RNA Assay: A new method for contemporary genomics and precision medicine via liquid biopsy.

Pai-Chi Teng

171
Impact of baseline serum IL-8 on metastatic hormone-sensitive (mHSPC) prostate cancer outcomes in the phase III CHAARTED trial (E3805).

Lauren Christine Harshman

172
Impact of DNA damage repair (DDR) mutations on treatment outcomes in men receiving conventional therapy for metastatic castration resistant prostate cancer (mCRPC).

Alex S. Carlson

173
Circulating tumor DNA-targeted sequencing to reveal germline and somatic alterations that can guide decision-making in metastatic castration-resistant prostate cancer.

Baijun Dong

174
Circulating-free DNA (cfDNA) as biomarker of taxane resistance in metastatic castration-resistant prostate cancer (mCRPC).

Edoardo Francini

176
Plasma cell-free DNA (cfDNA) profiling of copy number variation (CNV) to identify poor prognostic biomarkers in metastatic castration-resistant prostate cancer (mCRPC).

Edmond Michael Kwan

177
The effect of abiraterone acetate treatment on CREB and the development of abiraterone acetate resistance in prostate cancer cells.

Wenting Pan

178
Genomic characteristics associated with clinical activity of rucaparib in patients (pts) with BRCA1 or BRCA2 (BRCA)-mutated metastatic castration-resistant prostate cancer (mCRPC).

Wassim Abida

180
Copy number amplification of androgen receptor in cell-free DNA is a potential prognostic factor in patients with CRPC.

Itsuto Hamano

181
CDK12 upregulation and adverse correlation with tumor-associated immune cell infiltrates in prostate cancer.

Marie C. Hupe

182
Biomarker analysis of the phase III IPATential150 trial of first-line ipatasertib (Ipat) plus abiraterone (Abi) in metastatic castration-resistant prostate cancer (mCRPC).

Zhen Shi

183
Association of circulating tumor cell chromosomal instability with worse outcomes in men with mCRPC treated with abiraterone or enzalutamide.

Landon Carter Brown

185
Assessment of inherited DNA repair defects in African-American and Caucasian men with prostate cancer.

A. Oliver Sartor

186
Biomarker analysis (CTC and ctDNA/RNA) of GT0918 (Proxalutamide) new AR blocker in phase I mCRPC patients with dose escalation.

Karl Zhou

187
Treatment outcomes in metastatic prostate cancer patients with DNA damage repair mutations.

Daniel Kwon

188
Testosterone recovery as biomarker for overall and cause-specific survival in combined treated patients with high-risk and locally advanced prostate cancer.

Mathew Deek

189
Molecular underpinnings of RB status as a biomarker of poor outcome in advanced prostate cancer.

Amy C. Mandigo

190
Circulating tumor (ct) DNA-based comprehensive genomic profiling to identify microsatellite instability (MSI) and defective DNA damage repair (DDR) in prostate cancer (PCa) patients.

Leylah M. Drusbosky

191
<i>CDK12</i>-mutated prostate cancer (PC): Clinical outcomes to standard therapies and immune checkpoint blockade.

Michael Thomas Schweizer

193
MiR-27a-3p: An AR-modulatory microRNA with a distinct role in prostate cancer progression and therapy.

Foteini Kalofonou

194
Mismatch repair deficiency in metastatic prostate cancer (PC): Response to PD-1 blockade and standard therapies.

Laura Graham

195
Next-generation sequencing (NGS) of tumor tissue from >4000 men with metastatic castration-resistant prostate cancer (mCRPC): The PROfound phase III study experience.

Maha H. A. Hussain

196
High-exosomal AKR1C3 mRNA expression as a marker of poor efficacy of abiraterone in metastatic PCa patients.

Sha Zhu

197
Androgen receptor cfDNA longitudinal mutational analysis in metastatic castrate-resistant prostate cancer.

Elisa Marie Ledet

199
Comparison of Caucasian and African-American DNA repair alterations in men with metastatic prostate cancer.

Ellen Jaeger

200
Circulating tumor DNA (ctDNA) landscape in metastatic castrate-resistant prostate cancer patients with germline alterations.

Marcus W. Moses

201
Elevated circulating CCL2 in prostate cancer patients.

Justin Lin

202
Biomarkers of prolonged time to treatment failure in metastatic castration-resistant prostate cancer patients treated with abiraterone or enzalutamide: A real life patients-based nomogram and web app.

Maysa Tamara Silveira Vilbert

203
Characterization of Wnt signaling pathway (WSP) aberrations in advanced prostate cancer.

Fady Ghali

204
Addition of abiraterone to first-line long-term hormone therapy in prostate cancer (STAMPEDE): Model to estimate long-term survival, quality-adjusted survival, and cost-effectiveness.

Caroline Sarah Clarke

205
Androgen deprivation therapy and statin therapy in prostate cancer patients.

Kin Chung Lai

206
Relationship between Geriatric 8 screening score and treatment selection in patients with prostate cancer.

Shingo Hatakeyama

210
The psychological impact of early prostate cancer: A prospective evaluation.

Hadas Dresler

211
Cost-effectiveness of upfront therapeutic options in low-volume de novo metastatic hormone-sensitive prostate cancer.

Neil Rohit Parikh

212
Prognostic value of novel inflammation index for patients with metastatic castration-resistant prostate cancer.

Yasutaka Yamada

213
The impact of time-to-castration resistance on survival in patients with metastatic hormone-naïve prostate cancer: A multicenter retrospective study.

Teppei Okamoto

214
Role of soft tissue metastases on tumor progression in castrate-resistant metastatic prostate cancer.

Kathleen Ruchalski

215
Evaluation of bone metastasis and prognosis of prostate cancer with bone metastasis during standard hormonal therapy and chemotherapy: A report of PROSTAT-BSI multicenter registry in Japan.

Atsushi Mizokami

216
[18F]Fluciclovine-PET/MRI use in monitoring response to androgen deprivation therapy in men with prostate cancer following initial staging.

Samuel Joseph Galgano

217
The role of 68Ga-DOTATATE for evaluation of patients with metastatic castration-resistant prostate cancer (mCRPC).

Mehmet Asim Bilen

218
Radiotherapy (RT) guided by ultra‐small superparamagnetic iron oxide (USPIO)-contrast MRI staging for patients with advanced or recurrent prostate cancer.

Yun Rose Li

221
Comparative efficacy of local versus systemic salvage therapies for recurrent prostate cancer after primary radiotherapy.

Glenn Bauman

222
Extension of bone marrow involvement and cytopenias in patients with metastatic castration-resistant prostate cancer (mCRPC).

Daniel D Almeida Preto

223
Real-world utilization of radium-223 (Ra-223) for the treatment of metastatic castration-resistant prostate cancer (mCRPC): A U.S. tertiary oncology center analysis.

Rana R. McKay

224
Treatment decision making in metastatic prostate cancer (mPC).

Alicia K. Morgans

225
Prognostic factors that affect survival outcomes in men with metastatic castration-resistant prostate cancer (mCRPC) treated with radium-223.

Esmail Mutahar Al-Ezzi

227
Preliminary outcomes of a prospective observational study of combinatorial abiraterone acetate/enzalutamide (AA/Enz) and radical radiotherapy (RT) in nonmetastatic node-positive (N+M0) prostate cancer (PCa).

Mark Ting Le Tan

228
Radium-223 in the treatment of metastatic castrate-resistant prostate cancer: A real-world Irish experience.

Niamh Peters

229
Review of the real-world prevalence of mHSPC, nmCRPC, mCRPC, and gene alterations associated with HRR in prostate cancer (PC).

Neal D. Shore

230
Factors associated with positive germline testing results in men with prostate cancer following NCCN guideline expansion.

Trevor Charles Hunt

231
Family history and germline alterations in metastatic prostate cancer patients.

Whitley Hatton

232
Quality of life of prostate cancer (PCa) patients with testosterone deficiency symptoms (TDS) before initiation of gonadotropin-releasing hormone (GnRH) agonist therapy: Subgroup analysis of EQUINOXE study.

Stephane Droupy

233
The impact of race and insurance status on survival of prostate cancer patients.

Trevanne Rose Matthews Hew

235
Survey of ADT-induced estrogen deficiency-related side effects in a contemporary cohort of men with advanced prostate cancer.

Robert H. Getzenberg

236
Safety and effectiveness of radium-223 dichloride (Ra-223) in patients with mCRPC in real-world setting: A Japanese post-marketing study (PMS).

Shunji Takahashi

237
Lymph node metastasis to predict overall survival in oligometastatic prostate cancer in Asian patients.

Junryo Rii

238
The effect of treatment sequence on overall survival for men with metastatic castration-resistant prostate cancer: A multicenter retrospective study.

Shingo Hatakeyama

239
Efficacy of sequential therapy comprising of docetaxel, abiraterone, enzalutamide, and cabazitaxel in patients with castration-resistant prostate cancer.

Akiyuki Yamamoto

240
The efficacy of metastasis-directed radiation therapy (MDRT) for oligometastatic castration-resistant prostate cancer (CRPC).

Akira Nagahara

241
Impact of nadir PSA level and time to nadir during initial androgen deprivation therapy on prognosis in patients with metastatic castration-resistant prostate cancer.

Itsuto Hamano

242
Blood platelet volume to predict treatment-specific outcomes of metastatic castration-resistant prostate cancer.

Wataru Fukuokaya

243
Effect of core needle biopsy number on intraductal carcinoma diagnosis in patients with metastatic castration-sensitive prostate cancer.

Masashi Kato

245
Prevalence of ARV7 in Asian metastatic castrate-resistant prostate cancer (mCRPC) patients using multiple detection platforms.

Johan Chan

246
Preliminary results of a prospective assessment of androgen receptor splice variants in mCRPC patients undergoing androgen receptor targeted agents.

Giulio Francolini

247
Changes in conditional net survival and dynamic prognostic factors in patients with newly diagnosed metastatic prostate cancer.

Shintaro Narita

248
Characterization of metastatic spinal cord compression from prostate cancer.

Jianbo Wang

276
Transcriptome profiling of NRG Oncology/RTOG 9601: Validation of a prognostic genomic classifier in salvage radiotherapy prostate cancer patients from a prospective randomized trial.

Felix Y Feng

277
Analysis of small non-coding RNAs in urinary exosomes to classify prostate cancer into low-grade (GG1) and higher-grade (GG2-5).

Laurence Klotz

278
Evaluation of Proclarix, a prostate cancer risk score, used together with magnetic resonance imaging for the diagnosis of clinically significant prostate cancer.

Halyey Pye

279
Artificial intelligence for streamlined immunofluorescence-based biomarker discovery in prostate cancer.

Claire Marie de la Calle

281
Integrating comprehensive genomic profiling into the clinical management of prostate cancer patients: A single institution community practice experience.

Neal D. Shore

282
Pathologic outcomes of MRI invisible tumors in prostate cancer.

Sandeep Gurram

283
Does size matter? Lesion size as an indicator of number of cores needed to detect clinically significant prostate cancer.

Amir H. Lebastchi

284
TMPRSS2: ERG expression in prostate cancer—Imaging and clinicopathological correlations.

Vittorio Fasulo

285
A phase IIa randomized placebo-controlled trial of pomegranate fruit extract/POMx in subjects with clinically localized prostate cancer undergoing active surveillance.

David Frazier Jarrard

286
Detection of significant prostate cancer through magnetic resonance imaging targeted biopsy of PI-RADS3 lesions in African American patients based on prostate specific antigen density threshold of 0.15 ng/ml²: Analysis of patient population from the Vatti

Shaheen Riadh Alanee

288
Detection of clinically significant prostate cancer after negative fusion and systematic biopsy.

Jeffrey Twum-Ampofo

289
Advancing age and the risk of adverse pathology at radical prostatectomy in men with biopsy Gleason score 6 prostate cancer.

Daniel Kim

290
Risk factors which predict biopsy upgrading over time in active surveillance for prostate cancer.

Peter Eoin Lonergan

291
GLUT1 expression in high-risk prostate cancer: Correlation with 18F-FDG-PET/CT and clinical outcome.

Frederic Pouliot

293
Association of PI-RADS categories and PSA density with active surveillance progression in patients with prostate cancer.

Alex Z. Wang

295
Characterization of PSMA and 18F-fluciclovine transporter gene expression in localized prostate cancer.

Carissa Chu

296
Comparison of micro-ultrasound and multiparametric MRI imaging for prostate cancer: A multicenter prospective analysis.

Laurence Klotz

297
Disparities in receipt of molecular imaging in biochemical recurrent prostate cancer.

Hala Borno

298
Clinical utility of PSA density and PI-RADS for deferring biopsy for the detection of clinically significant prostate cancer.

Matthew Truong

300
18-year prostate cancer-specific mortality after prostatectomy, brachytherapy, external beam radiation therapy, hormonal therapy, or monitoring for localized prostate cancer.

Annika Herlemann

301
PSA status after neoadjuvant androgen deprivation therapy before high-dose-rate brachytherapy as biomarker for prediction of long-term outcome in high-risk prostate cancer patients.

Trude Wedde

305
Acute patient-reported toxicities after proton therapy or intensity-modulated radiotherapy for prostate cancer.

Kimberly Gergelis

306
Influence of node-positive disease after radical prostatectomy on biochemical recurrence and oncologic outcomes in men with prostate cancer.

Samuel L. Washington

307
Clinical utility of biomarkers 4K score, SelectMDx and ExoDx with MRI for the detection of high-grade prostate cancer.

Vittorio Fasulo

308
Contemporary racial disparities in PSA screening in a large, integrated health care system.

James T. Kearns

309
The deleterious association between proton pump inhibitors and prostate cancer specific death.

Hanan Goldberg

311
Prostate cancer survivorship care plans: What we are failing to tell men after treatment?

Youngjee Choi

312
A prospective comparison of MRI-planned versus CT-planned radiotherapy for prostate cancer.

Daniel R Schmidt

313
A randomized phase III trial between adjuvant docetaxel and surveillance after radical radiotherapy (RT) for intermediate and high-risk prostate cancer (PC): Quality-of-life results (QoL) in SPCG-13 trial.

Pirkko-Liisa Kellokumpu-Lehtinen

315
Quality of life outcomes from a phase III trial exploring optimal sequencing of androgen deprivation therapy with external beam radiotherapy in localized prostate cancer.

Soumyajit Roy

320
A randomized phase II study of apalutamide (APA), androgen deprivation therapy (ADT), or APA + ADT in patients (pts) with biochemically relapsed (BCR) prostate cancer (PC).

Rahul Raj Aggarwal

321
A comparison of sipuleucel-T (sip-T) product parameters from two phase III studies: PROVENT in active surveillance prostate cancer and IMPACT in metastatic castrate-resistant prostate cancer (mCRPC).

Ashley Ross

323
Phase II trial of definitive radiotherapy with leuprolide and enzalutamide in high-risk prostate cancer.

Claire Marie de la Calle

325
Eight-year outcomes of a phase III randomized trial of conventional versus hypofractionated high-dose intensity modulated radiotherapy for prostate cancer (CRUK/06/016): Update from the CHHiP Trial.

David P. Dearnaley

328
Stereotactic pelvic radiotherapy with HDR boost for dose escalation in intermediate and high-risk prostate cancer (SPARE): Efficacy, survival, and late toxicity outcomes.

Andrew Loblaw

330
The risk of death from prostate cancer in men with Gleason Score 3+4 prostate cancer treated using brachytherapy with or without a short course of androgen deprivation therapy.

David Dewei Yang

332
Stereotactic body radiation therapy with androgen deprivation therapy for unfavorable-risk prostate cancer.

Sagar Anil Patel

333
Adjuvant docetaxel for high-risk localized prostate cancer: Update of NRG Oncology/RTOG 0521.

Howard M. Sandler

334
Phase II trial of neoadjuvant chemohormonal therapy (NAC) in prostate cancer (PC) with response assessment using PSMA PET/MRI.

Christos Kyriakopoulos

335
A systematic review and network meta-analysis of FDA approved treatment options in men with nonmetastatic, castration-resistant prostate cancer (M0CRPC).

Irbaz Bin Riaz

336
Biopsy positivity in prostate cancer patients undergoing mpMRI-targeted radiation dose escalation.

Jessica Meshman

337
Clinical-genomic sub-classification of high-risk prostate cancer: Implications for tailoring therapy and clinical trial design.

Vinayak Muralidhar

338
Loss of SNAI2 in prostate cancer and effect on patient response to androgen deprivation therapy.

Niall Corcoran

340
Predicting radiation-induced immune trafficking and activation in localized prostate cancer.

Scott Williams

341
Periprostatic venous androgen levels in a subset of patients with prostate cancer: An investigation into a novel role of testosterone in localized prostate cancer.

Lewis Thomas

344
Immunosuppressive milieu of high-risk localized prostate cancer.

Victor Ricardo Adorno Febles

345
Trends and oncological outcome of testosterone recovery after androgen deprivation therapy in prostate cancer patients who received external beam radiotherapy.

Akinori Takei

347
Fraction genome altered (FGA) to regulate both cell autonomous and non-cell autonomous functions in prostate cancer and its effect on prostate cancer aggressiveness.

Goutam Chakraborty

349
Tumor cell intrinsic androgen biosynthesis by 3β-hydroxy steroid dehydrogenase (HSD3B1) to modulate radiosensitivity in prostate cancer cells.

Shinjini Ganguly

350
Outcomes of men with ductal prostate cancer undergoing definitive therapy for localized disease.

Weranja Kalana Bodhisiri Ranasinghe

353
Early diagnosis of prostate cancer, AABH (Aspartyl Asparaginyl β-hydroxylase), a predictive biomarker: A serum immunoassay and personalized medicine.

Kiarash Moshiri

356
Natural history of an immediately detectable PSA following radical prostatectomy: A description of a contemporary cohort.

Peter Eoin Lonergan

357
Influence of caseload on survival of patients (pts) with localized prostate cancer (PC) after definitive radiation therapy (DRT).

Sarmad Sadeghi

358
Association of salvage cryoablation with decreased utilization of androgen deprivation therapy for recurrent prostate cancer after radiotherapy.

J Kellogg Parsons

359
Treatment timing in localized high-risk prostate cancer treated with radiation and androgen deprivation therapy.

Shaakir Hasan

360
Physical activity assessment among men undergoing genetic counseling for inherited prostate cancer: A teachable moment.

Veda N. Giri

361
The relationship between socioeconomic status and treatment for prostate cancer in a universal healthcare system: A population-based analysis.

Justin Oake

362
Rates and determinants of prostatectomy in prostate cancer (PCa) patients with node-positive disease.

Lova Sun

364
The prevalence of cardiovascular disease and its risk factors among prostate cancer patients treated with and without androgen deprivation.

Jehonathan H. Pinthus

365
Stereotactic body radiotherapy boost toxicity for high and intermediate-risk prostate cancer: Report of a multi-institutional study.

Irving D. Kaplan

366
Adjuvant radiotherapy following radical prostatectomy for prostate cancer: A systematic review and meta-analysis.

Tobias Engel Ayer Botrel

367
Redefining the role of adjuvant versus salvage radiation therapy for prostate cancer after radical prostatectomy for T3 disease and/or positive margins.

Barry W. Goy

368
A tale of lineage plasticity: Intense neoadjuvant testosterone lowering therapy in localized prostate cancer (PCa) harboring high-risk genomic signatures.

Fatima Karzai

369
The efficacy and safety of radical prostatectomy and radiotherapy in high-risk prostate cancer: A systematic review and meta-analysis.

Zhipeng Wang

370
Utilization of androgen deprivation therapy (ADT) and stereotactic body radiation therapy (SBRT) for localized prostate cancer (PC) in the United States (US).

Trevor Joseph Royce

371
Determinants of biochemical failure and distant metastases-free survival in high-risk prostate cancer patients treated with external beam radiotherapy.

Avinash Pilar

372
Stereotactic radiotherapy +/- HDR boost for unfavorable-risk prostate cancer: Comparison of efficacy, survival, and late toxicity outcomes.

Andrew Loblaw

374
Adjuvant docetaxel after definitive radiotherapy for high-risk prostate cancer: A meta-analysis of randomized clinical trials.

Ray Manneh Kopp

376
High-dimensional single cell-based immune profiling of the tumor immune microenvironment in prostate cancer.

Michela Masetti

377
Significance of distinct specifically enriched missense TP53 mutations in prostate cancer.

Irina Vasilevskaya

388
Evaluation of the oncologic benefit of adjunctive surgery at time of postchemotherapy retroperitoneal lymph node dissection (PC-RPLND).

Tim Nestler

389
Validation of the two best models to predict “benign” pathohistology in patients with advanced nonseminomatous germ cell tumors (NSGCT) undergoing postchemotherapy retroperitoneal lymph node dissection (PC-RPLND).

Tim Nestler

394
The use of DNA promoter methylation testing for prostate cancer diagnosis in the Department of Veterans Affairs.

Kyung Min Lee

416
Predictive capacity of miRNA-375 in identifying teratoma in post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND).

Alexander P. Kenigsberg

TPS7
A multicenter phase II study of avelumab in patients with locally advanced or metastatic penile cancer (PC) who are unfit for, or have progressed on or after platinum-based chemotherapy: (ALPACA).

Husam Alqaisi

TPS249
Phase 0 study to assess [111In]-DOTA-h11B6 to target human kallikrein-2 (hk2) in men with metastatic castration-resistant prostate cancer.

Michael J. Morris

TPS250
A phase I study to evaluate PSCA-targeting chimeric antigen receptor (CAR)-T cells for patients with PSCA+ metastatic castration-resistant prostate cancer (mCRPC).

Tanya B. Dorff

TPS251
Single-arm, phase II study to evaluate the safety and efficacy of sacituzumab govitecan in patients with metastatic castration-resistant prostate cancer who have progressed on second generation AR-directed therapy.

Joshua Michael Lang

TPS252
A phase II study of M6620 in combination with carboplatin compared with docetaxel in combination with carboplatin in metastatic castration-resistant prostate cancer.

Atish Dipankar Choudhury

TPS254
Targeting resistant prostate cancer with ATR and PARP inhibition (TRAP trial): A phase II study.

Zachery R. Reichert

TPS255
A phase Ib/II open-label study of tazemetostat (TAZ) plus enzalutamide (E) or abiraterone/prednisone (A/P) in chemotherapy-naive patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

Wassim Abida

TPS256
Phase III study of pembrolizumab (pembro) plus olaparib versus enzalutamide (enza) or abiraterone acetate (abi) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) who progressed on chemotherapy: KEYLYNK-010.

Evan Y. Yu

TPS258
Phase III study of pembrolizumab (pembro) plus enzalutamide (enza) versus placebo plus enza for metastatic castration-resistant prostate cancer (mCRPC): KEYNOTE-641.

Julie Nicole Graff

TPS259
VISION: An international, prospective, open-label, multicenter, randomized phase III study of 177Lu-PSMA-617 in the treatment of patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC).

A. Oliver Sartor

TPS260
A multicenter, randomized, controlled phase II study: Efficacy and safety of PSMA-targeted radioligand therapy I-131-1095 (1095) plus enzalutamide (enza) in 18F-DCFPyL PSMA scan avid, metastatic castration-resistant prostate cancer (mCRPC) patients post-a

Evan Y. Yu

TPS261
Phase I study of AMG 160, a half-life extended bispecific T-cell engager (HLE BiTE) immune therapy targeting prostate-specific membrane antigen (PSMA), in patients with metastatic castration-resistant prostate cancer (mCRPC).

Ben Tran

TPS262
Phase III study of pembrolizumab (pembro) plus docetaxel and prednisone for enzalutamide (enza)- or abiraterone acetate (abi)–pretreated patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): KEYNOTE-921.

Daniel Peter Petrylak

TPS264
TALAPRO-2: A placebo-controlled phase III study of talazoparib (TALA) plus enzalutamide (ENZA) for patients with first-line metastatic castration-resistant prostate cancer (mCRPC).

Neeraj Agarwal

TPS265
Dosimetry of 177Lu-PSMA-617 for the treatment of metastatic castration-resistant prostate cancer: A sub-study of the VISION trial.

Jens Kurth

TPS266
A phase II study of onvansertib in combination with abiraterone and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC).

David Johnson Einstein

TPS267
Prospective trial of nivolumab (Nivo) plus radium-223 (RA) in metastatic castration-resistant prostate cancer (mCRPC) evaluating circulating tumor DNA (ctDNA) levels as a biomarker of response.

Benjamin Louis Maughan

TPS268
A multicenter phase IIb trial to evaluate the efficacy and tolerability of ModraDoc006/r in subjects with metastatic castration-resistant prostate cancer (mCRPC), suitable for treatment with a taxane (NCT04028388).

Ulka N. Vaishampayan

TPS269
A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer.

Vivek Narayan

TPS270
A phase Ib/IIa study of rucaparib (PARP inhibitor) combined with nivolumab in metastatic castrate-resistant prostate cancer.

Akash Patnaik

TPS272
A phase Ib/II, open-label, platform study evaluating the efficacy and safety of AB928-based treatment combinations in participants with metastatic castrate-resistant prostate cancer.

David R. Wise

TPS273
Phase II trial of a DNA vaccine encoding prostatic acid phosphatase (pTVG-HP) and nivolumab (Nivo) in patients (pts) with nonmetastatic, PSA-recurrent prostate cancer (PCa).

Hamid Emamekhoo

TPS274
A phase II study of sEphB4-HSA in metastatic castration-resistant prostate cancer (mCRPC).

Michael C. Burn

TPS275
Chemokine signaling and MAPK/ERK pathway for advanced prostate cancer treatment response.

Yazan Numan

TPS382
A phase Ib/II trial of perioperative intratumoral MVA-BN-brachyury (MVA) plus systemic PROSTVAC and atezolizumab (Atezo) for intermediate-risk and high-risk localized prostate cancer (AtezoVax).

Benjamin Louis Maughan

TPS383
PROTEUS: A randomized, double-blind, placebo (PBO)-controlled, phase III trial of apalutamide (APA) plus androgen deprivation therapy (ADT) versus PBO plus ADT prior to radical prostatectomy (RP) in patients with localized high-risk or locally advanced pr

Mary-Ellen Taplin

TPS385
DASL-HiCAP (ANZUP1801): The impact of darolutamide on standard therapy for localized very high-risk cancer of the prostate—A randomized phase III double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive

Tamim Niazi