ASCO-GU 2019 前立腺癌関連演題一覧
ESPOIR Vol. 2 No. 1
Abstract No.
Title

1st Author

1
PACE: Analysis of acute toxicity in PACE-B, an international phase III randomized controlled trial comparing stereotactic body radiotherapy (SBRT) to conventionally fractionated or moderately hypofractionated external beam radiotherapy (CFMHRT) for locali

Nicholas John Van As

2
A randomized trial comparing fluorocholine-PET/CT with conventional imaging in prostate cancer.

Scott Williams

3
SABR in high-risk prostate cancer: Outcomes from two prospective clinical trials with and without elective nodal irradiation.

Yasir Alayed

4
Time to PSA nadir and the risk of death from prostate cancer following radiation and androgen deprivation therapy.

Luke Roy George Pike

5
Rectal toxicity results for patients treated with HDR brachytherapy as monotherapy versus dose-escalated external beam radiotherapy for localized prostate cancer.

Jacob Samuel Parzen

10
Active surveillance and watchful waiting for low-risk prostate cancer in black patients: A population-based analysis.

Santino Butler

11
“Management Migration” in United States patients diagnosed with localized prostate cancer from 2010-2015.

Santino Butler

12
Conservative management of low-risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database.

Amandeep R Mahal

13
Management of low-risk prostate cancer in a population-based cohort of Australian men between 2008 and 2016.

Wee Loon Ong

15
Prospective head-to-head comparison of 18F-fluciclovine and 68Ga-PSMA-11 PET/CT for localization of prostate cancer biochemical recurrence after primary prostatectomy.

Jeremie Calais

16
Second cancer following radical prostate cancer treatment.

Bjorg Yksnoy Aksnessaether

17
Genomic validation of three-tiered sub-classification of high-risk prostate cancer.

Vinayak Muralidhar

18
GATA2 exosomal mRNA: A novel urine biomarker for the diagnosis of clinically significant prostate cancer.

Jungreem Woo

19
Are prostate cancer patients with BRCA1 and BRCA2 mutations safe for active surveillance?

Marc Dall'era

20
Outcomes of the patients with pT0 on first protocol biopsy during active surveillance for early prostate cancer: From the PRIAS-JAPAN study.

Takuma Kato

21
External beam radiation therapy and brachytherapy boost versus radical prostatectomy and adjuvant radiation therapy for high-risk prostate cancer.

Vinayak Muralidhar

22
Direct evidence of a clonal and tumor-directed T cell response to prostate cancer brachytherapy.

Scott Williams

26
Radiation-related lymphopenia after pelvic nodal irradiation for prostate cancer.

Sunil W Dutta

27
Stereotactic body radiotherapy (SBRT) versus conventional fractionated intensity-modulated radiotherapy (CF-IMRT) for patients with early-stage localized prostate cancer: One-year late toxicity results from a prospective randomized phase II study.

Darren M.C. Poon

28
The effect of the timing of biochemical failure after external beam radiotherapy or low-dose-rate brachytherapy for definitive prostate cancer treatment.

Jay P. Ciezki

29
Phase II trial enzalutamide and androgen deprivation therapy (ADT) with salvage radiation in men with high-risk PSA recurrent prostate cancer (PC): The STREAM trial.

Andrew J. Armstrong

30
SelectMDx versus Prostate Health Index in the identification of high-grade prostate cancer.

Gretchen Hoyer

33
Multi-institutional analysis of synchronous prostate and rectosigmoid cancers.

Corbin Jacobs

36
Impact of compliance on outcomes for patients on active surveillance for prostate cancer.

Jay Detsky

38
Do elderly men (>75) harbor more aggressive prostate cancer? Comparison of decipher and PAM50 TESTS among different age groups.

Hanan Goldberg

39
Long-term follow-up after radiotherapy for prostate cancer with and without rectal hydrogel spacer: A pooled prospective evaluation of quality of life.

Zachary Seymour

40
Impact of putative chemopreventative agents on prostate cancer diagnosis.

Hanan Goldberg

41
Prostate cancer-related quality of life and risk for anxiety and depression.

Shauna McManus

42
Identifying molecular determinants of response to apalutamide (APA) in patients (pts) with nonmetastatic castration-resistant prostate cancer (nmCRPC) in the SPARTAN trial.

Felix Y Feng

43
Validation and physiological association of changes in magnetic resonance imaging radiomic features in response to androgen deprivation therapy in patients with high-risk prostate cancer.

Hannah Tharmalingam

45
Does tumor location affect prostate cancer prognosis?

Jun Akatsuka

46
The impact of intratumoral heterogeneity on prognostic biomarkers in localized prostate cancer.

Harry Brastianos

48
The predictive value of DRE in the modern era of prostate cancer diagnostics.

Joel Marcus Andersson

51
Multi-institutional analysis of high-risk prostate cancer patients treated with stereotactic body radiotherapy.

Naomi Y Jiang

52
Early predicting factor for biochemical failure for patients with intermediate and high-risk prostate cancer treated by definitive radiotherapy.

Hye Jin Kang

54
Genomic analysis and clinical outcomes of Primary Gleason Pattern 5 (PG5) prostate cancer (PCa) treated with radical prostatectomy (RP).

Pedro Isaacsson Velho

55
Inflammatory bowel disease and risk of prostate cancer: A matched-cohort analysis.

Adam Weiner

56
Molecular characterization of longitudinally tracked prostate cancer foci in men on active surveillance for low risk disease.

Jeffrey J. Tosoian

58
A multibiomarker approach to predict prostate cancer pathology outcomes.

Pamela Paris

59
Hypofractionated dose painting IMRT using 20 fractions for intermediate to high risk localised prostate cancer: Two-year outcome data (BIOPROP20, NCT02125175).

Isabel Syndikus

60
A phase I pilot study of preoperative radiotherapy for prostate cancer: Long-term toxicity and oncologic outcomes.

Noelia Sanmamed

62
Activity of NEO2734, a novel dual inhibitor of both BET and CBP-P300, in SPOP-mutated prostate cancer.

Yuqian Yan

63
A study of intense neoadjuvant testosterone lowering therapy with goserelin and enzalutamide (Enza) in high-risk prostate cancer (PC) with multiparametric MRI (mpMRI).

Fatima Karzai

64
Predictors of prostate cancer-specific anxiety following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer.

Kamran Salari

65
Cost implications of multi-parametric magnetic resonance imaging in prostate cancer active surveillance.

Michelle Yu

66
Management of isolated local failures following stereotactic body radiation therapy for low to intermediate risk prostate cancer.

Nicolette Drescher

67
Ten year treatment complication outcomes of radical prostatectomy versus external beam radiation therapy versus brachytherapy for 1,503 patients with intermediate risk prostate cancer.

Barry W. Goy

68
Is there a correlation between Gleason score and maximum standardized uptake value in locally advanced prostate cancer patients?

Onal Cem

70
Role of magnetic resonance imaging-transrectal ultrasound fusion targeted biopsy in the detection of prostate cancer in biopsy-naïve men: A literature based meta-analysis of randomized trials.

Xiang Tu

71
Correlation between PSA kinetics and detection rate of PSMA-PET in the setting of biochemical recurrent prostate cancer: A systematic review and meta-analysis.

Ricardo Pereira Mestre

72
Racial disparities in survivorship care adherence among Medicare beneficiaries with prostate cancer.

Ravi Bharat Parikh

74
MiR-34a to enhance the radiosensitivity of 22RV1 and 22RV1-radiation resistance prostate cancer cell lines.

John Thoms

75
Cascade testing of men with prostate cancer in families with a spectrum of inherited cancers: Importance of attention to race.

Veda N. Giri

77
Providers’ inability to estimate health literacy among African American (AA) patients (pts) with early prostate cancer (PCa).

William Martin-Doyle

78
Moderately hypofractionated radiotherapy for localized prostate cancer: Long-term outcomes for 854 consecutive patients treated over 10 years (70 Gy in 2.5 Gy/fraction).

Omar Y. Mian

80
Four-year outcomes of hypofractionated proton therapy for localized prostate cancer.

Amardeep S. Grewal

81
The molecular hallmarks and clinical consequences of tumor hypoxia in prostate cancer.

Bhandari Vinayak

82
Machine learning approaches to improve prostate cancer outcome.

Ronnie Rodrigues Pereira

83
Evaluating non-hormonal therapy in a phase II trial of SM-88 for rising PSA prostate cancer.

Benjamin Adam Gartrell

84
Health literacy is a barrier to shared decision making in early prostate cancer (PCA) among African American (AA) men.

William Martin-Doyle

86
Immune infiltrate with CD8 low or PDL1 high associated with metastatic prostate cancer after radical prostatectomy (RP).

Cecile Vicier

87
Prospective evaluation of a new patient decision aid to enhance prostate cancer screening decision-making.

Michael Austin Brooks

88
Cribriform pattern, Genomic Prostate Score, and adverse pathology at radical prostatectomy in a cohort of prostate cancer patients initially on active surveillance.

Kyle Brian Zuniga

89
Outcomes of active surveillance for African-American men with prostate cancer: Results of a matched analysis.

Lewis Thomas

91
Cost-effectiveness of a two-gene urine biomarker assay in MRI strategies for the initial detection of prostate cancer.

Tim Govers

92
Trends in complementary and alternative medicine use among newly diagnosed prostate cancer patients.

Kyle Brian Zuniga

94
Clinical utility study of confirms mdx for prostate cancer in a community urology practice.

Paul Yonover

95
Clinical and genetic determinants of toxicity and quality-of-life (QOL) outcomes for SBRT in Asian prostate cancer.

Janice Ser Huey Tan

96
Validation of a two-gene mRNA urine test for detection of high-grade prostate cancer in German men.

Derya Tilki

98
Preoperative trial of neoadjuvant abiraterone plus or minus cabazitaxel: Early results.

Jaime Omar Herrera-Caceres

99
Impact of testosterone replacement therapy after radiation therapy on prostate cancer outcomes.

Reith Sarkar

100
Impact of testosterone replacement therapy after radical prostatectomy on prostate cancer outcomes.

Reith Sarkar

102
Efficacy and toxicity from phase II study of dose escalation to intraprostatic tumor nodule in localized prostate cancer.

Julia Murray

104
One and done?: Utility of PSA density as a predictor of number of cores needed to detect clinically significant prostate cancer.

Graham Hale

105
Brachytherapy use for favorable-risk prostate cancer continues to decline in both academic and community centers despite superior survival compared to dose-escalated external beam radiation therapy.

Kevin H. Nguyen

108
MRI targeted biopsy dramatically increases detection of clinically significant prostate cancer while reducing the risk of indolent cancer detection.

Michael Ahdoot

109
Optimizing the use of androgen deprivation therapy in men with localized intermediate risk prostate cancer in the era of modern dose-escalated radiation therapy.

Sagar Anil Patel

110
MRI-TRUS fusion-guided biopsy in obese patients: Does it reduce risk of prostate cancer upgrade on final pathology compared to systematic 12-core biopsy?

Samuel A Gold

111
Incidence and pathological features of metachronous bladder cancer in prostate cancer patients treated with brachytherapy or radical prostatectomy in a single institution.

Kotaro Obayashi

114
The impact of Charlson Comorbidity Index on survival outcomes in men with prostate cancer who underwent definitive prostate radiotherapy.

Ahmed I. Ghanem

115
Racial disparities in late-stage prostate cancer: A SEER database analysis 2005–2015.

Jianqing Lin

116
The cost of prostate cancer care to society and to patients in the United States.

Nicholas George Zaorsky

118
Overall survival outcomes with the use of adjuvant chemotherapy, radiation therapy and hormone therapy in high-risk, very-high-risk and node-positive prostate cancer post radical prostatectomy: A NCDB analysis.

Alina Basnet

119
State rurality does not increase risk of prostate cancer death.

Alexander Geoffrey Shaw Anderson

121
Racial differences in long-term prostate cancer specific mortality following conservative management for low-risk prostate cancer: A population-based study.

Grace L. Lu-Yao

123
Intraductal carcinoma of the prostate in prostate biopsy samples: Correlation with pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer patients.

Sha Zhu

125
Increasing utilization of multi-parametric magnetic resonance imaging in prostate cancer active surveillance.

Avinash Maganty

126
Radiogenomic characterization of multifocal prostate cancer.

Simpa Samuel Salami

127
The value of transperineal prostate apical zone biopsy in predicting urethral or apical margin status after radical prostatectomy in prostate cancer.

Jindong Dai

128
The validation of the 2014 International Society of Urological Pathology (ISUP) grading system for patients with high-risk prostate cancer: A single-center retrospective study.

Jiandong Liu

129
Marijuana use history in patients presenting with localized prostate cancer.

Romaine Charles Nichols

130
Reduced risk of prostate cancer in a cohort of Lithuanian diabetes mellitus patients.

Ausvydas Patasius

131
Late toxicity described using patient reported outcomes measures (PROMS) in men treated with salvage radiation following primary high intensity focal ultrasound (HIFU) for localized prostate cancer.

Reena Davda

133
Prostate cancer in young men: Our experience.

Joao Vasco Barreira

134
Experience of a single Brazilian center on PSMA-PET in biochemical recurrence in patients with prostate cancer.

Paulo Sergio Lages

139
Incidence of hypocalcemia in patients with castration-resistant prostate cancer treated with denosumab: Data from a non-inferiority phase III trial assessing prevention of symptomatic skeletal events (SSE) with denosumab administered every four weeks (q4w

Silke Gillessen

140
ARAMIS: Efficacy and safety of darolutamide in nonmetastatic castration-resistant prostate cancer (nmCRPC).

Karim Fizazi

141
Final analysis of phase III LATITUDE study in patients (pts) with newly diagnosed high-risk metastatic castration-naïve prostate cancer (NDx-HR mCNPC) treated with abiraterone acetate + prednisone (AA+P) added to androgen deprivation therapy (ADT).

Karim Fizazi

142
Initial results from a phase II study of nivolumab (NIVO) plus ipilimumab (IPI) for the treatment of metastatic castration-resistant prostate cancer (mCRPC; CheckMate 650).

Padmanee Sharma

143
Assessment of circulating tumor cell number as a transitional surrogate endpoint for survival in phase II trials for metastatic castration-resistant prostate cancer.

Howard I. Scher

144
Updated analysis of progression-free survival with first subsequent therapy (PFS2) and safety in the SPARTAN study of apalutamide (APA) in patients (pts) with high-risk nonmetastatic castration-resistant prostate cancer (nmCRPC).

Eric Jay Small

145
Keynote-365 cohort a: Pembrolizumab (pembro) plus olaparib in docetaxel-pretreated patients (pts) with metastatic castrate-resistant prostate cancer (mCRPC).

Evan Y. Yu

146
Genomic drivers of poor prognosis and enzalutamide resistance in metastatic castration-resistant prostate cancer.

William S. Chen

147
Cost-effectiveness of metastasis-directed therapy in the setting of oligometastatic hormone-sensitive prostate cancer.

Neil Rohit Parikh

148
A multicentric phase II randomized trial of docetaxel (D) plus enzalutamide (E) versus docetaxel (D) as first-line chemotherapy for patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): CHEIRON study.

Orazio Caffo

149
Late administration of luteinizing hormone-releasing hormone (LHRH) agonists and the impact on testosterone suppression in the real-world management of prostate cancer.

Przemyslaw Twardowski

150
Efficacy of docetaxel and androgen receptor axis-targeted agents in castration-resistant prostate cancer patients with intraductal carcinoma of the prostate.

Akiyuki Yamamoto, None

151
Measurement science of the androgen receptor splice variant-7 protein in primary and castration-resistant prostate cancer tissue.

Adam Sharp

152
Targeting mediator subunits CDK8/CDK19 for treatment of advanced prostate cancer.

Marie C. Hupe

153
Quality of life differences for LHRH-antagonist versus LHRH-agonist in special patient groups with cardiovascular comorbidities and higher tumor burden in patients with hormone-sensitive prostate cancer (hsPCa).

Jan Lehmann

154
Response to PARP inhibitor therapy in metastatic castrate-resistant prostate cancer (mCRPC) patients with BRCA1/2 versus ATM mutations.

Catherine Handy Marshall

155
Outcome, costs and dollar value of docetaxel and abiraterone in prostate cancer.

Helmy M. Guirgis

157
A circulating tumor cell RNA assay for dynamic assessment of androgen receptor signaling inhibitors sensitivity in metastatic castration-resistant prostate cancer.

Yu Jen Jan

158
Low incidence of microsurges with biodegradable polymer-delivered, subcutaneously-administered leuprolide acetate in prostate cancer patients.

Eleni Efstathiou

159
Predictors of germline DNA damage repair gene mutations (gDDRm) in patients (pts) with metastatic castration-resistant prostate cancer (CRPC).

Steven Yip

160
A Genome-wide association study of metastatic prostate cancer.

Craig Teerlink

161
A retrospective observational study assessing bone metastases (mets) detection and management of patients (pts) with castration-resistant prostate cancer (CRPC) in Canada.

Fred Saad, MD

163
Prostate cancer cost-of-care and evaluation of traditional cost control measures.

Dhruv Bansal

164
A phase II, open-label, multi-arm study of TAS-115 for castration-resistant prostate cancer patients with bone metastases.

Hiroji Uemura,

166
Impact of the USPSTF recommendations on prostate cancer stage migration and de-novo metastatic prostate cancer.

Yu-Wei Chen

167
The effect of VERU-111, a novel oral inhibitor of α and β tubulin, on tumor growth in the human castration-resistant, AR-variant prostate cancer (PCa) model 22Rv1.

Mark Christopher Markowski

168
Enzalutamide versus flutamide for castration-resistant prostate cancer after combined androgen blockade therapy with bicalutamide: A multicenter randomized phase II trial (OCUU-CRPC study).

Taro Iguchi

169
A phase I/II study of proxalutamide (GT0918), a potent androgen receptor blocker, in patients with mCRPC progressed after both hormonal therapy and chemotherapy.

Nicholas J. Vogelzang

170
Keynote-365 cohort b: Pembrolizumab (pembro) plus docetaxel and prednisone in abiraterone (abi) or enzalutamide (enza)-pretreated patients (pts) with metastatic castrate resistant prostate cancer (mCRPC).

Christophe Massard

171
Keynote-365 cohort C: Pembrolizumab (pembro) plus enzalutamide (enza) in abiraterone (abi)-pretreated patients (pts) with metastatic castrate resistant prostate cancer (mCRPC).

Peter C.C. Fong

172
Pembrolizumab in men with heavily treated metastatic castration-resistant prostate cancer (mCRPC).

Matthew D Tucker

173
A phase I and randomized phase II study of cabozantinib plus docetaxel and prednisone (C+DP) versus docetaxel and prednisone (DP) alone in metastatic castrate-resistant prostate cancer (mCRPC).

Munjid Al Harthy

174
Experience with sipuleucel-T in metastatic castration-resistant prostate cancer (mCRPC) with visceral spread from PROCEED.

Nicholas J. Vogelzang

175
Associations of cell cycle genetic variants with aggressive prostate cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.

Melissa Huynh

176
In geriatric evaluation, some iadl (Katz) scale items are more predictive of efficacy and toxicity than ADL (Lawton) scale or Charlson Comorbidity Index in metastasic castration-resistant protate cancer (mCRPC) patients treated with cabazitaxel in a weekl

Miguel Ángel Climent

177
Real-world PROCEED registry data: Sipuleucel-T in elderly men with metastatic castration-resistant prostate cancer (mCRPC).

Andrew J. Armstrong

178
Age-related variation in gene alteration frequency in metastatic prostate cancer.

Zachary Rockow Chalmers

179
A noninvasive prognostic biomarker for metastatic castration-resistant prostate cancer: Very small nuclear circulating tumor cells.

Pin-Jung Chen

180
A retrospective analysis of treatment patterns in metastatic castration-resistant prostate cancer patients treated with radium-223.

A. Oliver Sartor

181
A genetic risk score to personalize prostate cancer screening, applied to population data.

Minh-Phuong Huynh-Le

182
CCN3/NOV as a functional driver and prognostic biomarker of prostate cancer bone metastasis.

Veronique Ouellet

183
The clinical impact of bone scan (BS) flare with enzalutamide (ENZA) in men with metastatic castration-resistant prostate cancer (mCRPC).

Andrew J. Armstrong

184
Characterization of PSA at death in patients with metastatic castration-resistant prostate cancer.

Krishna Bikkasani

185
A phase III, randomized, double-blind, placebo-controlled study of enzalutamide in men with nonmetastatic castration-resistant prostate cancer: Post-hoc analysis of PROSPER by prior therapy.

Ugo De Giorgi

186
Clinical outcomes in Caucasian (C), African American (AA) and Asian men with metastatic castration-resistant prostate cancer (mCRPC).

Susan Halabi

187
Docetaxel in older patients for metastatic prostate cancer.

Frances May Mark

188
Whole blood FOLH1 mRNA expression and treatment response in metastatic castration-resistant prostate cancer (mCRPC).

Edmond Michael Kwan

189
Clinical progression at initiation of a life-extending therapy (LET) in metastatic castration-resistant prostate cancer (mCRPC) is associated with a poor prognosis, whatever the treatment-line: Results of the CATS retrospective registry.

Nicolas Delanoy

191
Determining androgen inactivation status in prostate cancer by [18F] DHT PET.

Ziqi Zhu

192
Outcomes of high-dose whole pelvic simultaneous integrated boost IMRT in patients with pelvic lymph node-positive prostate cancer.

Takashi Mizowaki

193
The Veterans Health Administration Precision Oncology Program for Advanced Prostate Cancer Patients: Expanding tumor NGS opportunities to a broader patient population.

Alexandra Sokolova

194
Next Generation Sequencing (NGS) in metastatic castration resistant prostate cancer (mCRPC) to identify targets for individualized treatment: Is it feasible in daily routine?

Axel Heidenreich

195
Identification, incidence and clinical outcomes of patients (pts) with hypermutated prostate cancer (PC).

Simon Yuen Fai Fu

197
Eltanexor (KPT-8602), a second-generation selective inhibitor of nuclear export (SINE) compound, in patients with metastatic castration-resistant prostate cancer (mCRPC).

Jingsong Zhang

198
Treatment efficacy of abiraterone (abi), enzalutamide (enza) or cabazitaxel (caba) in metastasic castration resistant prostate cancer patients (mCRPC) after progression to docetaxel plus androgen deprivation therapy (ADT) in hormone sensible disease.

Miguel Ángel Climent

200
Genomic determinants of sensitivity to bipolar androgen therapy (BAT) in castrate-resistant prostate cancer (CRPC).

Michael Thomas Schweizer

201
Metastasis-free survival as a predictor of overall survival in non-metastatic castration-resistant prostate cancer.

Richard Gagnon

202
Phase II study of niraparib in patients with metastatic castration-resistant prostate cancer (mCRPC) and biallelic DNA-repair gene defects (DRD): Preliminary results of GALAHAD.

Matthew Raymond Smith

203
Plasma AR status and cabazitaxel in heavily-treated metastatic castration-resistant prostate cancer (mCRPC).

Vincenza Conteduca

204
A multidisciplinary team-based approach to mitigate the impact of androgen deprivation therapy in prostate cancer: A randomized phase II study.

YaoYao Guan Pollock

205
Prostate cancer-derived anti-GRP78 autoantibodies compromise the blood-brain barrier and accelerate atherosclerosis progression in vivo.

Ali Al-Hashimi

206
Investigating a novel recombinant antibody to attenuate prostate cancer progression by targeting cell surface GRP78.

Ali Al-Hashimi

207
ARV7 and ARFL mRNA in blood to predict androgen receptor inhibitors and docetaxel response in castration-resistant prostate cancer patients.

Mercedes Marin

209
The efficacy of enzalutamide for castration-resistant prostate cancer (CRPC) patients with intraductal carcinoma of the prostate (IDC-P).

Hideji Kawanishi

210
Genomic characterization of pulmonary-metastatic prostate cancer: A unique molecular subtype.

Eugene Shenderov,

211
Impact of prostate specific antigen doubling time on time to metastasis and overall survival in non-metastatic castration-resistant prostate cancer patients.

Stephen J. Freedland

212
Overall survival by race in chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone acetate or enzalutamide.

Megan Ann McNamara

213
Final analysis of a phase II study of MRI based functional imaging of bone metastases in men with metastatic castrate-resistant prostate cancer (mCRPC) receiving Cabozantinib.

Arpita Desai

214
Positron emission tomography with 18F-fluciclovine to predict recurrence in post-treatment recurrent prostate cancer and its role in altering treatment plans.

Julio Chong

215
An updated analysis evaluating skeletal related events (SREs) in CTRIAL-IE 13-21: Phase II trial of radium-223 (R223) in combination with enzalutamide (ENZA) for patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

John Patrick Greene

216
Pembrolizumab for metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel: Updated analysis of KEYNOTE-199.

Emmanuel S. Antonarakis

217
Immunogenomic landscape of neuroendocrine small cell prostate cancer.

Lucia Nappi

218
Circulating tumor (ct) DNA-based genomic profile of prostate cancer (PCa) patients with elevated carcinoembryonic antigen (CEA).

Pannaga G. Malalur

219
Quality-of-life (QoL) assessment and reporting in prostate cancer: A systematic review of phase III trials published between 2012 and 2016.

Laura Marandino

220
Next generation N-terminal domain androgen receptor inhibitors with improved potency and metabolic stability in castration-resistant prostate cancer models.

Ronan Le Moigne

221
The role of enzalutamide-induced hyperactive Jak2-Stat5 feed-forward signaling loop on enzalutamide-resistant prostate cancer growth and as a therapeutic target for second-line treatment.

Vindhya Udhane

222
Interpreting survival outcomes for African-American (AA) patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) treated with sipuleucel-T (SIP-T) with number needed to treat to benefit (NNTB).

Kelvin A. Moses

223
Radium 223 treatment in metastatic castrate-resistant prostate cancer: Impact of sequencing on survival—Real-world outcomes from a single UK centre.

Xue Yan Jiang

224
Immunogenomic landscape of Neuroendocrine Prostate Cancer (NEPC).

Alison Ferguson

225
Morphology-predicted, large-scale transition (LST) number in circulating tumor cells (CTC) as a biomarker of chromosomal instability (CIN) to assess early resistance to standard of care (SOC) drugs in mCRPC.

Howard I. Scher

226
Discovery of targetable mutational signatures in advanced prostate cancer (aPC) using machine learning and next-generation sequencing (NGS) of circulating tumor DNA (ctDNA).

Edwin Lin

227
Clinicopathologic and genomic characterization of parenchymal brain metastases (BM) in prostate cancer (PCa).

Jose Mauricio Mota

228
Results of a 50 patient single-centre phase II prospective trial of Lutetium-177 PSMA-617 theranostics in metastatic castrate-resistant prostate cancer.

Michael Hofman

229
Tumor testing in men with prostate cancer to predict for germline DNA-damage repair mutations.

Maria Isabel Carlo

230
Clinical validation of circulating cytokines as markers of prognosis and response to docetaxel in men with metastatic castration-resistant prostate cancer.

Kate Lynette Mahon

232
Early 18F-FDHT PET/CT as a predictor of treatment response in mCRPC treated with enzalutamide.

Hilde Hoving

233
Association between urinary, bowel, and hormonal treatment-related symptoms and clinical outcomes in nonmetastatic castration-resistant prostate cancer (nmCRPC): PROSPER study.

Fred Saad

234
Health-related quality of life (HRQoL) in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with olaparib in combination with abiraterone.

Noel W. Clarke

235
The influence of treatment sequence in the prognostic value of TMPRSS2-ERG as a biomarker of taxane resistance in castration-resistant prostate cancer.

Oscar Reig

236
Clinical events associated with cumulative corticosteroid use in patients with castration-resistant prostate cancer: An administrative claims analysis.

Benjamin H Lowentritt

237
Adverse events of special interest assessed by review of safety data in enzalutamide castration-resistant prostate cancer (CRPC) trials.

Bertrand F. Tombal

238
Cell plasticity associated to taxane-resistance in preclinical cell models and in circulating tumor cells from metastatic castration-resistant prostate cancer patients.

Ruth Montalbo

239
Risk of subsequent dementia from androgen deprivation therapy (ADT) versus orchiectomy among men with prostate cancer.

Ravi Bharat Parikh

240
Methylation-associated miR193b silencing activates master drivers of aggressive prostate cancer.

Ying Zhang Mazzu

241
Efficacy of abiraterone and enzalutamide in patients who had disease progression within twelve months of completing docetaxel for metastatic castration sensitive prostate cancer.

Gang Chen

242
Plasma cell-free DNA-based prognosis in metastatic hormone sensitive prostate cancer.

Manish Kohli

243
The effect of a structured exercise intervention on CTCs and platelet cloaking in patients with metastatic prostate cancer.

Lauren Brady

244
Impact of new systemic therapies on outcomes of patients with non-metastatic castration resistant prostate cancer (nmCRPC).

Cecile Vicier

245
DNA repair germline pathogenic mutation associations with treatment duration and family history in prostate cancer.

James Vu

247
Aberrations in androgen receptor ctDNA varies by race in metastatic castrate-resistant prostate cancer.

Bryce Raymon Christensen

248
Identification of bone involvement in patients with prostate cancer recurrence using 18F-fluciclovine PET/CT and impact on subsequent management.

Michael S Kipper

249
TP53 mutations in circulating tumor DNA in men with metastastic castration-resistant prostate cancer mCRPC.

Lynne Chapman

250
Preliminary results of a two stage phase II study of 18F-DCFPyL PET-MR for enabling oligometastases ablative therapy in subclinical prostate cancer.

Rachel Glicksman

251
The tumor immune microenvironment differs between metastatic castrate resistant prostate cancer (CRPC) and hormone sensitive prostate cancer (HSPC).

Kobe Chi Yung Yuen

252
Clinical characteristics of men with prostate cancer and evaluation of NCCN prostate cancer guidelines on germline genetic testing outcomes.

Samantha Greenberg

253
Clinical outcome with concurrent or layered treatment with radium-223 and abiraterone: A retrospective study of real-world experience with patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

Daniel J. George

254
Evaluation of circulating tumor DNA (ctDNA) with respect to germline alterations in metastatic castrate resistant prostate cancer patients.

Peter Steinwald

255
Pembrolizumab (pembro) in heavily pretreated metastatic castrate-resistant prostate cancer (mCRPC).

Marcus Marie Moses

256
Treatment patterns and outcomes for metastatic castration-resistant prostate cancer (mCRPC) in a real-world setting: A retrospective study of greater than 2500 patients.

Celestia S. Higano

257
Lessons learned from the metastatic castration-resistant prostate cancer phase I trial of EPI-506, a first-generation androgen receptor N-terminal domain inhibitor.

Ronan Le Moigne

258
Germline DNA repair mutations in men with prostate cancer are less frequent in African Americans as compared with Caucasians.

Piper L.W. Nicolosi

259
ARV-110: An oral androgen receptor PROTAC degrader for prostate cancer.

Taavi Neklesa

260
First-in-field small molecule inhibitors targeting BRN2 as a therapeutic strategy for small cell prostate cancer.

Daksh L. Thaper

262
Performance of the 17-gene genomic prostate score test in men with prostate cancer (PCa) managed with active surveillance (AS): Results from the Canary Prostate Active Surveillance Study (PASS).

Daniel W. Lin

263
Apalutamide (APA) or enzalutamide (ENZA) in men with nonmetastatic castration-resistant prostate cancer (CRPC): A systematic review and network meta-analysis of randomized clinical trials (RCTs).

Irbaz Bin Riaz

264
Impact of treatment sequence in metastatic castration-resistant prostate cancer (mCRPC) on outcome in a prospective cohort study.

Rebeca Lozano

265
ctDNA and copy-number variant quantification in mCRPC at the time of progression.

Patrick Cotogno

266
Neutrophil-to-lymphocyte ratio as a prognostic biomarker for overall survival in men with advanced prostate cancer treated with platinum chemotherapy.

Panagiotis J. Vlachostergios

270
Assessing the real-world (RW) efficacy and toxicity of docetaxel (D) for the treatment of metastatic castrate sensitive prostate cancer (mCSPC): A single institution experience.

Seanthel Delos Santos

273
Sipuleucel-T to modify the B7-H3 immune checkpoint in men with castrate resistant prostate cancer.

Wei Phin Tan

274
Treatment facility volume and survival in patients with advanced prostate cancer.

Shreyas Joshi

275
EphB4-EphrinB2 receptor-ligand pair as a novel target in prostate cancer (PC).

Sarmad Sadeghi

276
Survival outcomes for adjuvant or salvage radiation in men with pN+M0 prostate cancer.

Jonathan David Tward

277
3βHSD1 immunohistochemistry and HSD3B1 genotype in prostate cancer.

JJ Haijing Zhang

278
Value of serum neuroendocrine markers in evaluation of neuroendocrine prostate cancer: A validation study using metastatic biopsies.

Panagiotis J. Vlachostergios

279
Plasma-based exploratory biomarker analysis to evaluate GT0918 in a phase I/II study in mCRPC patients.

Jianjun Yu

281
PEAX: Men with metastatic castrate-resistant prostate cancer (mCRPC) treated with either sipuleucel-T (SIP-T), enzalutamide (ENZA) or abiraterone acetate (ABI) undergoing cardiopulmonary exercise testing (CPET).

Michael Roger Harrison

283
Somatic alterations in a seven-gene DDR gene panel predicts platinum sensitivity in advanced prostate cancer patients.

Panagiotis J. Vlachostergios

286
Concomitant characterization of androgen receptor (AC) and immune checkpoints (ICs) in cell-free (cf) DNA and RNA from patients with metastatic castration resistant prostate cancer (mCRPC).

Sumanta K. Pal

287
Obesity and metastatic castration resistant prostate cancer: Results from the control arms of ASCENT2, MAINSAL and VENICE trials.

Alberto Martini

288
Utilization and outcomes of surgical castration in comparison to medical castration in metastatic prostate cancer.

Rohan Garje

291
German health service research with the focus on effectiveness of secondary-antiandrogen deprivation therapy (s-ADT) in prostate cancer patients with buserelin in daily practice.

Gerson Luedecke

292
Exploratory study of prognostic factors in mCRPC patients who administered enzalutamide focusing on early PSA decline and PSA kinetics at PSA progression: Results of retrospective multicenter study.

Yoshiyuki Miyazawa

293
Enzalutamide versus flutamide for castration-resistant prostate cancer after combined androgen blockade therapy with bicalutamide: A retrospective study.

Kosuke Hamada

294
Alkaline phosphatase (ALP) value at diagnosis of CRPC and response to primary androgen deprivation therapy may predict metastasis in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC).

Mori Keiichiro

295
A survey to determine patients’ (pts) opinions of a clinical trial (CT) comparing intermittent (int) versus continuous (cont) androgen receptor signaling inhibitor (ARSi) therapy for the treatment of advanced prostate cancer.

Cameron Phillips

296
Effect of IL-6 and related mediators on resistance to abiraterone acetate (abi) and enzalutamide (enza) in patients with metastatic castration-resistant prostate cancer (mCRPC).

Jacob J. Adashek

298
Timing of docetaxel chemotherapy and impact on outcomes in metastatic castrate-resistant prostate cancer (MCRPC).

Alastair Thomson

299
The oral α and β tubulin inhibitor, VERU-111, for the treatment of metastatic castration-resistant and androgen blocking agent-resistant prostate cancer in nonclinical toxicity studies.

Robert H. Getzenberg

300
Prognostic significance of lactate dehydrogenase-5 expression in patients with prostate cancer treated with androgen deprivation therapy and androgen receptor axis-targeted agents.

Wataru Fukuokaya

301
Preclinical evaluation of AMG 160, a next-generation bispecific T cell engager (BiTE) targeting the prostate-specific membrane antigen PSMA for metastatic castration-resistant prostate cancer (mCRPC).

Julie Bailis

302
The effect of androgen receptor splice variant 7 on the growth of castration-resistant prostate cancer and the efficacy of taxane chemotherapy.

Yasuomi Shimizu

303
Abiraterone acetate plus prednisone/prednisolone compared with enzalutamide in metastatic castration resistant prostate cancer before or after chemotherapy: A retrospective study of real-world data (ACES).

Prantik Das

304
Prostate cancer (PCa) incidence and severity in 821 hypogonadal men with and without testosterone therapy (TTh) in a controlled, observational registry implying more than 7,000 patient-years.

Ahmad Haider

305
Next generation sequencing of primary prostate cancer tumors to reveal potentially actionable opportunities for clinical management: The UNC experience.

Daniel James Crona

306
Biochemichal recurrence in prostate cancer after salvage surgery in correlation to the site of reccurrent disease.

David Pfister

307
Intermittent bicalutamide in recurrent non-metastatic castrate sensitive prostate cancer: A single institution experience.

Mark Prentice

308
The hematologic parameters in metastatic castration-resistant prostate cancer patients treated with abiraterone acetate.

Onal Cem

309
Patients with an extremely high prostate-specific antigen at prostate cancer diagnosis: A single institution analysis.

Qian Qin

310
PRINT: Prostate cancer intensive, non-cross reactive therapy for CRPC—Early observations of feasibility and efficacy.

Bobby Chi-Hung Liaw

311
Protection of prostate cancer cells from GSK-3β-induced oxidative stress by Il-8 through activating the mTOR signaling pathway.

Yi Sun

312
Integration of radium-223 dichloride (Xofigo) into clinical practice for the treatment of castration-resistant prostate cancer.

Catherine Mary Doyle

313
The value of AKR1C3 in predicting the therapeutic efficacy of abiraterone for patients with metastatic castration-resistant prostate cancer.

Jinge Zhao

314
Clinical significance of AR amplification from CF DNA among Japanese castration-resistant prostate cancer patients.

Shinichi Sakamoto

315
The association of PSA levels and survival outcomes in patients with chemotherapy-naïve, castration-resistant prostate cancer (CRPC) who were treated with androgen receptor signaling axis targeting agent (ARAT): A Japanese cohort study.

Tatsuya Shimomura

316
The outcome of loco-regional radiotherapy in metastatic castration-resistant prostate cancer patients treated with abiraterone acetate.

Berna Yildirim

317
Regional variations in online education test performance for prostate cancer care.

Hamsa Jaganathan

318
Clinical drivers for imaging testing in nonmetastatic castration-resistant prostate cancer: May they be optimized?—Data of “IDENTIFICA” study.

Eduardo Useros RodrÃguez

319
Continuous infusion 5-fluorouracil (5FU) as a novel treatment for heavily pretreated prostate cancer patients: An update.

Charlotte Manogue

320
Genomic changes of AR in ctDNA prior to enzalutamide in men with mCRPC after abiraterone acetate.

Leta Ko

321
Germline heterozygous BLM mutations and prostate cancer risk.

Elisa Ledet

322
Genetic testing patterns for homologous recombination repair (HRR) alterations in patients with metastatic prostate cancer (mPC): An assessment at the University of Rochester (UR).

Kerry Schaffer, MD

323
Clinical outcomes of a Dutch prospective observational registry of metastatic castration resistant prostate cancer (mCRPC) patients treated with radium-223 (Ra-223).

Rebecca Louhanepessy

325
Retrospective review of 11C-choline detected thoracic lesions in prostate cancer.

Muneeb Rehman

326
Synergistic effects of the PARP inhibitor olaparib and pharmacological ascorbate in castration-resistant prostate cancer.

Nicolas Gordon

687
Phase 3 study of androgen deprivation therapy (ADT) with enzalutamide (ENZA) or placebo (PBO) in metastatic hormone-sensitive prostate cancer (mHSPC): The ARCHES trial.

Andrew J. Armstrong

TPS136
Randomized phase III trial of 68Ga-PSMA-11 PET/CT molecular imaging for prostate cancer salvage radiotherapy planning [PSMA-SRT].

Jeremie Calais

TPS137
Preoperative radiotherapy for high-risk prostate cancer (PORT-PC) trial.

Himanshu Nagar

TPS138
The “ProPSMA Study” clinical trial protocol: A prospective randomized multi-center study of the impact of Ga-68 PSMA PET/CT imaging for staging high risk prostate cancer prior to curative-intent surgery or radiotherapy.

Michael Hofman

TPS328
A phase II trial in progress: Pamiparib, an investigational PARP inhibitor, in patients with metastatic castration-resistant prostate cancer and a circulating tumor cell homologous recombination deficiency (HRD) phenotype or BRCA defects.

Simon Chowdhury

TPS329
A randomized phase Ib/II study of nivolumab with or without BMS-986253 in combination with a short course of ADT in men with castration-sensitive prostate cancer (MAGIC-8).

Matthew Dallos

TPS330
Design of phase Ib/II study of oral VERU-111, an α and β-tubulin inhibitor, for the treatment of metastatic castration- and androgen-blocking-agent-resistant prostate cancer.

Mark Christopher Markowski

TPS331
Modulation of plasma lipidomic signature in metastatic castration-resistant prostate cancer (mCRPC).

Blossom Mak

TPS332
TheraP: A randomized phase II trial of [177Lu]-PSMA-617 theranostic versus cabazitaxel in progressive metastatic castration-resistant prostate cancer.

Michael Hofman

TPS333
Evaluating the clinical, environmental, genetic, and genomic profile of men with early-onset aggressive prostate cancer (PCa).

Ahmad Zarzour

TPS334
ODENZA: A study of patient preference between ODM-201 (darolutamide) and enzalutamide in men with metastatic castrate-resistant prostate cancer (mCRPC).

Geraldine Martineau

TPS335
ProSTAR: A phase Ib/II study of CPI-1205, a small molecule inhibitor of EZH2, combined with enzalutamide (E) or abiraterone/prednisone (A/P) in patients with metastatic castration-resistant prostate cancer (mCRPC).

Mary-Ellen Taplin

TPS336
A phase II study of onvansertib (PCM-075) in combination with abiraterone and prednisone in patients with metastatic castration-resistant prostate cancer.

David Johnson Einstein

TPS337
TALAPRO-2: A two-part, placebo-controlled phase III study of talazoparib (TALA) with enzalutamide (ENZA) in metastatic castration-resistant prostate cancer (mCRPC).

Neeraj Agarwal

TPS338
A phase II, dose finding, placebo-controlled, study of zuclomiphene citrate to amerliorate the frequency and severity of hot flashes caused by androgen deprivation in men with advanced prostate cancer.

Robert H. Getzenberg

TPS339
Phase I/II dose-escalation trial of fractionated dose 177Lu-J591 plus 177Lu-PSMA-617 for metastatic castration-resistant prostate cancer (mCRPC).

Scott T. Tagawa

TPS340
PROPEL: A randomized, phase III trial evaluating the efficacy and safety of olaparib combined with abiraterone as first-line therapy in patients with metastatic castration-resistant prostate cancer (mCRPC).

Noel W. Clarke

TPS341
A phase II study of nivolumab in patients with high-risk biochemically recurrent (BCR) prostate cancer (PCa).

David Johnson Einstein

TPS342
TALAPRO-1: An open-label, response rate phase II study of talazoparib (TALA) in men with DNA damage repair (DDR) defects and metastatic castration-resistant prostate cancer (mCRPC) who previously received taxane-based chemotherapy (CT) and progressed on g

Johann S. De Bono

TPS343
Genetic counseling processes and outcomes among prostate cancer patients (ProGen).

Donna Rachel Vatnick

TPS345
A randomized phase II study comparing cabazitaxel/prednisone to cabazitaxel alone in docetaxel-pretreated men with metastatic castration resistant prostate cancer (mCRPC): The CABACARE trial.

Carlo Buonerba

TPS346
Personalized use of metronomic cyclophosphamide for DNA repair deficient castration-resistant prostate cancer: A phase II trial.

Cameron Phillips

TPS347
A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer.

Vivek Narayan

TPS348
A phase III trial of docetaxel versus docetaxel and radium-223 (Ra-223) in patients with metastatic castration-resistant prostate cancer (mCRPC): DORA.

Michael J. Morris

TPS683
Phase Ib (COSMIC-021) trial of cabozantinib (C) in urothelial carcinoma (UC) or C in combination with atezolizumab (A) in patients (pts) with UC, castrate resistant prostate cancer (CRPC) or renal cell carcinoma (RCC).

Sumanta K. Pal