<< 一覧に戻る

総説

加齢と神経変性疾患:遺伝性パーキンソン病原因遺伝子の機能解析から明らかとなってきたミトコンドリアの品質管理機構

Mechanism of Mitochondrial Quality Control by Genes Responsible for Parkinson’s Disease

今居譲 斉木臣二服部信孝

アンチ・エイジング医学 Vol.7 No.6, 56-61, 2011

Summary
 Mitochondrial dysfunction has long been believed to be one of the major causes of the etiology of Parkinson’s disease (PD). The gene products for autosomal recessive juvenile PD, parkin and PINK1, have now turned out to be directly involved in the autophagic elimination of the damaged mitochondria called mitophagy, which is thought to be required for the maintenance of a healthy mitochondrial population in the cells or tissues. PINK1/Parkin-mediated mitophagy involves the activation of the ubiquitin-proteasome and autophagy machineries, which could also be significant to other familial or sporadic forms of PD. The latest progress in PD study suggests that at least some forms of juvenile PD are characterized as a mitochondrial disorder beyond that of a neurodegenerative disorder although the validation of the disease relevance of mitophagy awaits further study.

記事本文はM-Review会員のみお読みいただけます。

メールアドレス

パスワード

M-Review会員にご登録いただくと、会員限定コンテンツの閲覧やメールマガジンなど様々な情報サービスをご利用いただけます。

新規会員登録

※記事の内容は雑誌掲載時のものです。

一覧に戻る