Summary
Adiponectin, a physiologically active polypeptide secreted by adipocytes which exists abundantly in serum, shows insulin-sensitizing, anti-inflammatory and anti-atherogenic properties in rodents and humans. To find out the new effects of adiponectin in vivo, the model animal with hyperadiponectinemia has been needed. We fortunately succeeded to produce three lines of transgenic mice expressing human adiponectin in the liver. Two lines of these mice of had serum human adiponectin levels 20 times higher than normal human and exhibited 30 times higher serum levels of high molecular weight (HMW). We reported that these mice with hyperadiponectinemia had long life-span. Especially, the longevity effect of adiponectin under a high calorie chow was more remarkable than under a regular chow. Calorie restriction has only been established as a way of longevity in all species. If the fact that detailed functions of adiponectin lead to longevity will be identified, the development of calorie restriction mimetic or exercise mimetic might become possible.
全文記事
アディポネクチンとアンチエイジング
8 アディポネクチンと寿命―アディポネクチン高発現トランスジェニックマウスの作製とその解析結果から―
The Association between Adiponectin and Longevity ; Based on the Analysis of the Transgenic Mice Lines expressed Human Adiponectin Gene
掲載誌
アンチ・エイジング医学
Vol.7 No.3 53-57,
2011
著者名
小田辺修一
記事体裁
特集
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全文記事
疾患領域
代謝・内分泌
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栄養管理
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アンチエイジング
診療科目
糖尿病・代謝・内分泌科
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老年科
媒体
アンチ・エイジング医学
※記事の内容は雑誌掲載時のものです。